United States: Matt Kaeberlein had a terrible frozen shoulder a few years ago. His shoulder hurt so much that he couldn’t even throw a ball and had trouble sleeping. The doctor said that it might take a whole year to get better if he went through physical therapy.
Turning to Rapamycin: A Bold Experiment
Matt was frustrated, so he decided to try a medicine called rapamycin. Recently, some scientists who study how to help people live longer have started using this medicine. They hope it might help people stay healthy as they get older. Although nobody knows yet if it works for that, rapamycin has been shown to help mice live longer.
Remarkable Results: A Rapid Recovery
And he decided to try it Kaeberlein days. It was his “ first ever foray into the biohacking,” And he was very pleased with what happened next. “ Within two weeks, the fifty percent of the pain was literally gone,” he says and by the end if the 10 weeks, he had resigned range of motion and the pain was completely gone and never came back.
Though this man is no stranger to rapamycin and he’s also a biologist and co-founded the Dog Aging Project which is really a good deed to study how rapamycin influences dogs health spans. He’s also the former director or the Healthy Aging and Longevity Research Institute at the University of Washington.
Rapamycin: Approved for Transplants, Under Exploration for Aging
Firstly it was approved by the FDA or the use in the transplant patients in the late 1990s. At the high doses it suppresses the immune system. At the low doses the Kaeberlein says it seems to help the tamp down inflammation and it works by inhibiting a signaling pathway in the body called mTOR which appears to be a key regulator of lifespan and aging.
A Growing Interest in Off-Label Uses
This drug is not approved for pain or any kind of anti-aging but some physicians prescribe rapamycin off-label with the aim of fending off age- related conditions. Kaeberlein and his colleagues surveyed about almost 300 patients who take low doses benefited by many reports.
There is also some evidence from the patients who were transplanted that rapamycin may help improve oral health. As part of the study, his collaborators will also measure changes in participants’ microbiomes and biological clocks.